Treatment of Diabetic Retinopathy and Macular Edema
Chronic high blood sugar levels from the disease damage tiny blood vessels in the retina, causing them to leak fluid or blood into the retinal tissues. Damages to retinal blood vessels also causes bleeding into the posterior chamber of the eye that contains the normally clear vitreous gel.
Diabetic retinopathy is associated with the proliferation of a protein called vascular endothelial growth factor (VEGF) in the retina.
VEGF stimulates the production of new blood vessels in the retina to bring more oxygen to the tissue because retinal blood circulation is inadequate due to diabetes.
Unfortunately, these tiny new blood vessels that form in the retina in response to VEGF are fragile and increase in number, leading to additional fluid leakage, bleeding and scarring in the retina and progressive vision loss.
Blood vessel leakage from diabetic retinopathy can cause fluid to accumulate in the macula, which is the most sensitive part of the retina that is responsible for central vision and color vision.
This condition — called diabetic macular edema (DME) — is the primary cause of vision loss associated with diabetic retinopathy.
Lasers for diabetic retinopathy treatment
Laser treatment of diabetic eye disease generally targets the damaged eye tissue. Some lasers treat leaking blood vessels directly by "spot welding" and sealing the area of leakage (photocoagulation). Other lasers eliminate abnormal blood vessels that form from neovascularization.
Lasers also may be used to destroy non-essential tissue in the periphery of the retina, which may help reduce the production of VEGF and improve blood flow to the central retina.
After laser treatment of the peripheral retina, some blood flow bypasses this region and instead provides extra nourishment to the central portion of the retina. The resulting boost of nutrients and oxygen helps maintain the health of cells in the macula that are essential for detailed vision and color perception. However, some peripheral vision could be lost due to this treatment.
The two types of laser treatments commonly used to treat significant diabetic eye disease are:
Focal or grid laser photocoagulation. This type of laser energy is aimed directly at the affected area or applied in a contained, grid-like pattern to destroy damaged eye tissue and clear away scars that contribute to blind spots and vision loss. This method of laser treatment generally targets specific, individual blood vessels.
Panretinal laser photocoagulation (PRP). With this method, about 1,200 to 2,400 tiny spots of laser energy are applied to the periphery of the retina, leaving the central area untouched.
Treatment of clinically significant DME also entails using fluorescein angiography to provide images of the eye's interior. These images accurately guide application of laser energy, which helps "dry up" the localized swelling in the macula. A fluorescein angiogram also can identify the location of blood vessel leakage caused by proliferative diabetic retinopathy.
While laser treatment for diabetic retinopathy usually does not improve vision, the therapy is designed to prevent further vision loss. Even people with 20/20 vision who meet treatment guidelines should be considered for laser therapy to prevent eventual vision loss related to diabetes.
What to expect before, during and after laser treatment
Laser treatment typically takes place in a clinic or eye doctor's office and no overnight stay in a hospital is required.
Make sure you have someone drive you to and from the office or clinic on the day you have the procedure. Also, you'll need to wear sunglasses afterward because your eyes will be temporarily dilated and light sensitive.
Before the procedure, you will receive a topical anesthetic or possibly an injection adjacent to the eye to numb it and prevent it from moving during the laser treatment.
Your eye doctor will make these types of adjustments to the laser beam before it is aimed into the eye:
The amount of energy used
The size of the "spot" or end of the beam that is directed into the eye
The pattern applied by the laser beam onto the targeted area
A laser treatment typically lasts at least several minutes, but more time may be required depending on the extent of your eye condition.
During laser treatment, you might experience some discomfort, but you should feel no pain. Right after a treatment, you should be able to resume normal activities. You might have some discomfort and blurry vision for a day or two after each laser treatment.
The number of treatments you need will depend on your eye condition and extent of damage. People with clinically significant diabetic macular edema may require three to four different laser sessions at two- to four-month intervals to stop the macular swelling.
If you have proliferative diabetic retinopathy (PDR) — meaning that leakage of fluid has begun in the retina — the laser treatment should take from 30 to 45 minutes per session, and you may require up to three or four sessions.
Your chance of preserving your remaining vision when you have PDR improves if you receive panretinal laser photocoagulation as soon as possible following diagnosis.
Non-laser treatment of diabetic macular edema
Injection of corticosteroids or other medications into the eye — either directly or in the form of an injectable implant — sometimes is recommended over laser procedures for the treatment of diabetic macular edema.
Or in some cases, a combination of drug injections and laser treatment may be recommended.
As diabetic retinopathy worsens, in addition to VEGF, other small "signal" proteins (cytokines) are released by cells, causing additional inflammation in the retina that can cause or worsen DME.
Corticosteroids have been shown to have a beneficial effect by decreasing the amount of VEGF and other inflammatory cytokines produced by cells (a process called "downregulation"), which can lead to a reduction of diabetes-related macular edema.
Though the following medications reduce levels of several proteins associated with inflammation, they are generally classified as "anti-VEGF" medicines.
Anti-VEGF drugs or drug-releasing implants that are FDA-approved for injection into the eye for treatment of DME in the United States include:
Iluvien (Alimera Science)
Eylea (Regeneron Pharmaceuticals)
Iluvien is a tiny implant that delivers a sustained, slow release of a corticosteroid (fluocinolone acetonide) to treat diabetic macular edema. It is prescribed for patients who previously have been treated with corticosteroids and did not have a clinically significant rise in intraocular pressure (a potential side effect of corticosteroid use).
According to Alimera Sciences, a significant advantage of Iluvien over other treatments for DME is the longevity of its effect: Iluvien is designed to provide a sustained release of corticosteroid medication for 36 months, compared with other treatments that may last only a month or two.
Ozurdex is an implant that releases a sustained dose of dexamethasone (a corticosteroid) to the retina to treat diabetic macular edema. It is also used for the treatment of posterior uveitis and for macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) — two types of eye strokes.
Lucentis (ranibizumab) is an anti-VEGF medication marketed by Genentech. Clinical trials have shown that up to 42.5 percent of patients who were given monthly eye injections of Lucentis gained at least 15 letters in best corrected visual acuity (BCVA) on a standard eye chart two years after initiation of the treatment, compared with 15.2 percent of patients in a control group.
Another study found that Lucentis injections and Lucentis injections combined with laser photocoagulation both were significantly more effective than laser treatment alone for the treatment of DME.
Eylea (aflibercept) is an anti-VEGF drug marketed by Regeneron Pharmaceuticals for the treatment of DME. It is also approved for treatment of advanced age-related macular degeneration (AMD) and macular edema following retinal vein occlusion.
Studies that evaluated the results of monthly injections of Eylea compared with laser photocoagulation treatments for DME showed that Eylea treatments produced significantly better outcomes than the laser treatments. Patients who underwent Eylea treatments gained, on average, the ability to read approximately two additional lines on an eye chart, compared with almost no change in visual acuity in the control group.
Retisert (Bausch + Lomb) is another intraocular implant that delivers long-term, sustained release of a corticosteroid (fluocinolone acetonide) for the treatment of DME. Retisert is designed to deliver corticosteroid therapy inside the eye for up to 2.5 years, according to Bausch + Lomb. The device is implanted into the eye through a surgical incision in the sclera.
Risks associated with intraocular steroid treatment for DME include steroid-induced cataracts and glaucoma. Vision loss from cataracts usually can be restored with cataract surgery. To reduce the risk of glaucoma, your eye doctor might recommend preventive use of glaucoma eye drops or even glaucoma surgery.
Vitrectomy and other surgical treatments for diabetic eye disease
In some people who have proliferative diabetic retinopathy, bleeding into the vitreous (vitreous hemorrhage) makes laser photocoagulation treatment impossible because the blood obscures the surgeon's view of the retina.
If the vitreous hemorrhage fails to clear within a few weeks or months, a surgical procedure called a vitrectomy may be performed to remove the bloody vitreous and replace it with a clear gel-like material. After the vitrectomy, laser photocoagulation can be applied. The laser procedure is performed either at the time of the vitrectomy or shortly thereafter.
Retinal bleeding and vitreous hemorrhage also can cause bands of scar tissue to form. These bands of scar tissue can cause traction on the retina that may lead to a retinal detachment. If you have been diagnosed with diabetic retinopathy and experience flashes of light and a sudden loss of peripheral vision (both are symptoms of a detached retina), see your eye doctor immediately.