Heterochromia: 2 Different-Colored Eyes
What is heterochromia?
Heterochromia is the term used to describe when someone has more than one eye color. In many cases, this means each eye is a different color — for example, one eye is brown and the other eye is green — but it can also mean there are at least two distinct colors in different parts of one eye or both eyes.
SEE RELATED: The mystery surrounding hazel eyes
Heterochromia iridum and heterochromia iridis
When someone’s eyes have any form of multicoloration, they probably have heterochromia iridum or heterochromia iridis. Either name can be used to describe the condition mentioned above: eye-related heterochromia.
Different forms of heterochromia can affect skin and hair, so attaching iridum or iridis clarifies that only the eyes are affected.
Causes of heterochromia
A genetic mutation is believed to cause almost all congenital forms of heterochromia. The mutation is benign, meaning that it doesn’t relate to an underlying disease or illness and won’t cause any harm.
Animals can have heterochromia, too. At some point, you’ve probably noticed a Siberian husky, Australian shepherd or border collie with two different-colored eyes. Along with other domestic animals, these dogs experience the same genetic phenomenon as humans.
Heterochromia is usually harmless when present from birth or early development (congenital heterochromia), but it can also point to an underlying condition such as Waardenburg syndrome.
Less commonly, heterochromia can occur later in life due to disease, injury or the use of certain medications. This is called acquired heterochromia.
LEARN MORE ABOUT the causes of heterochromia.
Types of heterochromia
There are three main types of heterochromia, each with its own unique visual traits:
Complete heterochromia: Two “mismatched” eyes of completely different colors.
Sectoral heterochromia: Two-colored eyes that take on more of a “slice” or “wedge” pattern on each affected eye. Also called partial heterochromia, it represents the type with the most variety. The secondary color can look like a thin slice of color in one eye and take up two-thirds of the iris in another eye. It can occur in one or both eyes.
A condition called anisocoria can easily be confused with heterochromia, which was often the case with David Bowie. Anisocoria gives the appearance of two different eye colors, but the variation only relates to pupil size — which can cause one eye to look darker than the other — not the actual eye color.
STILL HAVE QUESTIONS? Check out our Heterochromia FAQs
Anisocoria: Variation and clinical observation with different conditions of illumination and accommodation. Investigative Ophthalmology & Visual Science. March 1991.
Page published in March 2019
Page updated in September 2021
Medically reviewed in May 2021