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Blepharoconjunctivitis: Causes, symptoms and treatment

Blepharoconjunctivitis occurs when both the lining of the eye (conjunctiva) and the eyelids are inflamed at the same time.

What is blepharoconjunctivitis?

Blepharoconjunctivitis is a combination of blepharitis and conjunctivitis. Blepharitis causes crusty, red and swollen eyelids. Conjunctivitis causes inflammation of the clear lining on the white part of the eye and the inside of the eyelids.

What causes blepharoconjunctivitis?

Blepharoconjunctivitis occurs due to inflammation and irritation. These can be caused by microorganisms, skin diseases, systemic health conditions, certain medications and underlying eyelid disorders. Some sources are more common than others. 


Staphylococcus aureus (the bacteria that causes staph infection). This is seen in acute (starting suddenly) infections of the eyelid and is caused by an overgrowth of bacteria. This bacterium can be resistant to penicillin and cephalosporin antibiotics — including methicillin. It is then called methicillin resistant staphylococcus aureus or MRSA.  

While MRSA blepharoconjunctivitis has become more common over the past two decades it can still be treated with many other antibiotics.

Staphylococcus epidermidis, Corynebacterium and Propionibacterium acnes. These bacteria are normally present on the skin. Overgrowth of these bacteria will cause more chronic (long-lasting) infections.

Moraxella catarrhalis.These bacteria can cause sinus and ear infections in children. They also sometimes live in old makeup. This is considered an uncommon cause of blepharoconjunctivitis.

Demodex folliculorum. A skin mite that is normally present on the skin of the face. When present in larger numbers, it can cause acne rosacea — a condition that causes flushing and small pimples of the face and nose. It also causes Demodex blepharitis.

Molluscum contagiosum. This is a type of pox virus that causes small, smooth wart-like lesions on the skin and usually infects children. It can cause blepharoconjunctivitis when the lesions are close to the eye.

Monkeypox virus. This infection can also cause blepharoconjunctivitis when lesions are close to the eye or by touching a lesion and then touching the eye. While uncommon this can cause severe scarring of the cornea.

Phthiriasis palpebrarum. This occurs when lice infect the eyelid and attach to the base of the eyelashes.

Herpes simplex virus type 1. This is a common cause of cold sores around the mouth and on the lips. The virus usually occurs in the eye in patients who have already been exposed — usually as a child.

Skin and systemic health conditions

Allergies and atopic disease. Atopic disease is typified by eczema, asthma and allergies. It can cause thickening of the eyelids and cause wrinkling and darkening of the skin around the eyes.

Vitamin B6 deficiency. In rare cases, this deficiency may be associated with angular blepharoconjunctivitis. Other signs and symptoms of this deficiency are skin rash, a swollen tongue, confusion and irritability. Pinpricks and numbness of the hands and feet may also occur.

Down syndrome. Blepharoconjunctivitis, blepharitis, styes and excess tearing are all more common in people with Down syndrome.

Seborrheic dermatitis. This condition affects the skin in areas that are normally more oily. It causes dandruff and a rash beside the nose, on the eyebrows and eyelids.


Dupilumab (Dupixent) — a medication for eczema. Blepharoconjunctivitis will begin after the medication is started and go away again once it is stopped.

Chemotherapy such as 5-fluorouracil — a treatment for cancer. It causes blepharoconjunctivitis along with other diseases of the surface of the eye.

Isotretinoin (Accutane) — a treatment for acne. It dries out the skin and blocks the formation of oils that are produced in the meibomian glands in the eyelid. Without these oils, the eye dries out, causing blepharoconjunctivitis.

Eyelid conditions

Ectropion and entropion. Aging, scarring, inflammation and allergies can cause the eyelid to tilt forward (ectropion) or fold inward (entropion). This allows bacteria to grow and causes the eye to dry out and become inflamed as the folded eyelid rubs on the eye surface.

Floppy eyelid syndrome. Aging, inflammation, excessive rubbing and being overweight can all cause the eyelids to become loose and more flexible. Floppy eyelid syndrome causes drying of the eye at night and increases the risk that the open eye rubs on the pillow.

Meibomian gland dysfunction (MGD). MGD becomes more common as we age but can be present at any age. It is seen in chronic cases of blepharoconjunctivitis and is more common in patients that have suffered from styes.

SEE RELATED: Eyelash lice: How do you get them and what are the treatments? 

Signs and symptoms of blepharoconjunctivitis

Some of the most common symptoms of blepharoconjunctivitis include:

Symptoms often occur in both eyes and may feel better or worse at different times. Many find that symptoms are particularly unpleasant in the morning, just after waking up.

SEE RELATED: Eyelid dermatitis : Causes, symptoms and treatment 

Types of blepharoconjunctivitis

Blepharoconjunctivitis can occur in one or both eyes, but it usually occurs in both. There are many types of blepharoconjunctivitis. Some are more severe than others. 

The different types of blepharoconjunctivitis can be categorized based on the part of the eyelid that is affected or what is thought to be the cause:


  • Anterior disease –  affecting the area of the eyelid at the base of the eyelashes

  • Posterior disease – associated with meibomian gland disease and affects the edge of the eyelid that touches the eyeball

  • Angular blepharoconjunctivitis – a rarer type of blepharoconjunctivitis caused by Moraxella or Staph bacteria


  • Seborrheic blepharoconjunctivitis – There are often signs of seborrheic dermatitis elsewhere on the face and dandruff of the scalp and eyebrows. The edge of the eyelid has greasy yellow to gray scales.

  • Atopic blepharoconjunctivitis – This condition is brought on by chronic allergies. It can involve the cornea in addition to the conjunctiva and eyelids. The eyelids will have dry scales that are not limited to the edge and may look like eczema.  

  • Molluscum contagiosum and monkeypox virus Small round skin lesions are present elsewhere on the body, and at least one lesion is close enough to the eye to shed viral particles onto the conjunctiva.  

  • Phthiriasis palpebrarum This is a sexually transmitted infection (STI) that causes small gray deposits the eggs of the lice at the base of the lashes. They cause redness and extreme itchiness.

  • Herpes simplex virus-1May appear as a simple rash or look more like fluid-filled blisters that break open and then form a crust.

  • Bacterial blepharoconjunctivitis – Can affect different parts of the eyelids. The conjunctivitis component is more likely to cause a thicker discharge.

  • Ocular rosacea – Associated with rosacea of the face, this is a condition caused by Demodex mites. The edge of the eyelids have round scurf at the base of the eyelashes (called collarettes). And there are small blood vessels that appear at the surface of the skin (called telangiectasia). 

A type of cancer called sebaceous cell carcinoma can look similar to blepharoconjunctivitis. Redness in both the conjunctiva and eyelids may appear, even without a cancerous mass. Lash loss can also occur. Patients that had a stye removed that grew back are more likely to have this condition. These symptoms should be examined to detect whether cancer may be present.

SEE RELATED: Eyelid cancer: Types, symptoms and treatments 

Blepharoconjunctivitis treatment

The standard treatment method for blepharoconjunctivitis is hygiene-focused. Some ways to achieve this include:

  • Washing the eyelashes with a specially formulated shampoo to remove dandruff and cleanse the area. Some of these shampoos contain antimicrobial agents, such as hypochlorous acid or tea tree oil. For best results, these antimicrobial shampoos should be allowed to soak into the skin.

  • Placing a warm compress over the eyes to soften the oil in the meibomian glands. This should be done for five to 10 minutes at a time. Followed by gently massaging the eyelids to help release oil from the clogged glands.

Artificial tears may also be helpful — both for rinsing the eyes and relieving dryness.

If blepharoconjunctivitis is associated with an underlying condition, that condition is treated first. The methods listed above should be used with other prescribed treatments when needed. 

It’s important to monitor healing, and seek help if your condition gets worse or does not respond to treatment. You may be given a topical antibiotic or steroid for one to two weeks if maintaining good hygiene isn’t enough. In some cases, antibiotic pills such as doxycycline and azithromycin are prescribed for longer periods of time.

Chronic blepharoconjunctivitis may result in:

  • Severe dry eye

  • Loss of the meibomian glands

  • Styes

  • Eyelid infection (called preseptal cellulitis)

  • Misdirected eyelashes

  • Growth of new eyelashes that rub on the cornea

  • Formation of calcifications inside the eyelids (concretions)

When to see a doctor

If you find yourself asking, “why won’t my eye infection go away?,” additional treatment may be required. Contact your eye doctor if your condition worsens, persists or returns after initial treatment.

Be sure to discuss with your doctor any medications, eye cosmetics or skin products you use. 

Additionally, be sure to stay up to date on annual comprehensive eye exams. Even if you haven’t noticed any changes in your visual clarity, it’s important to check for separate eye problems that need to be addressed.

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Moraxella Catarrhalis: A common cause of childhood illnesses. American Academy of Pediatrics. Accessed December 2022.

Molluscum contagiosum. Centers for Disease Control and Prevention. May 2015.

Mpox signs and symptoms. Centers for Disease Control and Prevention. September 2022.

Blepharoconjunctivitis secondary to dupilumab successfully treated with itraconazole. Dermatitis. American Contact Dermatitis Society. May 2019. 

Unilateral blepharoconjunctivitis due to monkeypox virus infection. Ophthalmology. American Academy of Ophthalmology. August 2022.

When blepharoconjunctivitis refuses to go away. Review of Ophthalmology. October 2008. 

Blepharitis. Texas Children’s Hospital. Accessed December 2022. 

Blepharitis. Ocular Surface Disease: Cornea, Conjunctiva and Tear Film. April 2013.

Prevalence of ophthalmological manifestations in pediatric and adolescent populations with Down syndrome: a systematic review of the literature. Systematic Reviews. April 2022.

Seborrheic dermatitis. Mayo Clinic. September 2022.

Herpes simplex infection of the eye: an introduction. Community Eye Health. March 2020.

Phthiriasis palpebrarum. Statpearls. December 2022.

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