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What Medications Make My Dry Eye Worse?


If you already have dry eyes, being prescribed the following categories of prescription and over-the-counter (OTC) medications may make your dry eye symptoms worse:

  • Antihistamines and decongestants
  • Hypertension medications
  • Hormone treatments
  • Pain relievers
  • Antidepressants
  • Acne medications
  • Gastrointestinal (GI) medications
  • Chemotherapy medicines
  • Antipsychotic medications

See Can Medications Cause Dry Eyes? for specific examples and brand names of medications that can make dry eyes worse.

If you feel your dry eye symptoms have worsened since starting a particular medicine, discuss this with the doctor who prescribed the medication to see if an equally effective alternative is available.

Page updated January 2018


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