Diabetic Retinopathy News
Archive (2008)

...continued from Current Diabetic Retinopathy News

Major Study Finds Most People With Type 1 Diabetes Develop Eye Disease

MADISON, Wis., November 2008 — Most people diagnosed with type 1 diabetes developed some form of diabetic retinopathy during a 25-year study conducted by University of Wisconsin researchers.

Risk factors for developing diabetic retinopathy included higher blood sugar levels, blood pressure and body mass, along with male gender. People with higher blood sugar levels also were at increased risk of developing more severe proliferative diabetic retinopathy (PDR).

Study results found that:

• Among 955 insulin-dependent people, 97 percent developed diabetic retinopathy (DR).
• The disease continued to progress in 83 percent of those diagnosed with DR.
• In those with DR, 42 percent developed the proliferative or more damaging form of the eye disease.

Researchers pointed out that people with a more recent diagnosis of diabetic retinopathy were less likely to have PDR, probably because of better and more modern management strategies aimed at controlling blood sugar and blood pressure.

Results of the Wisconsin Epidemiologic Study of Diabetic Retinopathy were published In the November issue of Ophthalmology.

Vision Loss More Likely With Diabetes

ATLANTA, October 2008 — Any adult with diabetes has an 11 percent chance of developing vision loss, according to U.S. Centers for Disease Control investigators.

A survey of 1,237 people with diabetes and 11,767 without also found that:

• People without diabetes have a 5.9 percent chance of developing vision impairment.
• Most vision impairment is correctable, with or without the diabetes association.
• Older age, low income and inadequate health insurance also were linked to increased likelihood of vision impairment in all groups.

Study results were published in the October issue of Archives of Ophthalmology.

Pain Relief Drug May Benefit Diabetic Retinopathy and Glaucoma

AUGUSTA, Ga., September 2008 — Researchers say pentazocine, a narcotic drug commonly used for pain relief and memory stimulation, appears to have "phenomenal" benefits for restoring health of retinal cells damaged by potentially blinding eye diseases including diabetic retinopathy and glaucoma.

Medical College of Georgia School of Medicine investigators tested pentazocine on mice with retinas damaged by a type of diabetic eye disease.

Findings that describe dramatic, positive results were published in the September issue of Investigative Ophthalmology & Visual Science.

The eye's retina is a light-sensitive membrane responsible for receiving and transmitting images to the brain. These photos show a healthy retina, one damaged by diabetes and one damaged and then treated with the drug, pentazocine.

Study results suggest that pentazocine binds with proteins known as sigma receptors to enhance beneficial roles related to improved cell function and protection from damage.

Investigators say additional studies will involve using mice bred without sigma receptors to determine more precisely how pentazocine works to restore damaged retinal cells. Other scientists currently are exploring the role of sigma receptors in treatment of diseases such as Alzheimer's, brain tumors and depression.

New Diabetes Medication May Slow Eye Damage

LOS ANGELES, June 2008 — A new diabetes medication known as rosiglitazone may help slow development of abnormal blood vessels in the inner back of the eye (retina) that can cause blindness in diabetic retinopathy, according to the June issue of Archives of Ophthalmology.

Jules Stein Eye Institute researchers compared medical records of 124 people who were taking rosiglitazone with those of 158 individuals who did not receive the same treatment. All people studied had diabetes, and fewer than 10 percent had a severe form of diabetic eye disease that had not yet involved development of abnormal blood vessels associated with proliferative diabetic retinopathy.

In three years, only 19.2 percent of the rosiglitazone group and 47.4 percent of the control group had progressed to the proliferative form of diabetic retinopathy.

Researchers said more comprehensive studies are needed to confirm benefits of rosiglitazone as a treatment for diabetic retinopathy.

Gene Appears Linked to Diabetic Eye and Kidney Disease

SALT LAKE CITY, May 2008 — Severe diabetic eye and kidney diseases appear linked to inheritance of a specific gene called EPO (erythropoietin), according to research led by Kang Zhang, MD, PhD, director of the Division of Ophthalmic Genetics at Moran Eye Center and ophthalmology professor at the University of Utah.

Researchers made the discovery and isolated the gene after comparing 1,618 diabetics who had both severe diabetic eye disease (proliferative diabetic retinopathy) and end-stage renal or kidney disease with 954 diabetics who did not have these diseases.

Future treatments of diabetic eye disease may involve finding ways to inhibit the activity of the EPO gene, researchers said. Findings were published in the May 5 online edition of the Proceedings of National Academy of Sciences journal.

Protein in Blood Vessels May Help Treat Serious Eye Diseases

SALT LAKE CITY, March 2008 — Serious eye diseases such as diabetic retinopathy and macular degeneration (AMD) may be treated in the future through activating a certain blood vessel protein that can help reverse or prevent eye damage.

In experiments involving mice, University of Utah School of Medicine researchers found that activity of the protein, Robo4, prevented or reversed abnormal blood vessel growth in the inner back lining of the eye (retina), where vision processing occurs.

Abnormal blood vessel growth causes potentially blinding eye damage in both diabetic retinopathy and AMD.

"Many diseases are caused by injury or inflammation destabilizing blood vessels and causing them to leak fluid into adjacent tissues as well," said Dean Y. Li, MD, PhD, senior author of a study published March 16 in Nature Medicine online.

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